I own a few 30-06 rifles.

A Browning M95 with iron sights. 17 kills with this one. Deer and antelope
A Mauser/Scout with a 19" barrel and 2X scout scope. 14 kills with this one. Deer and antelope.
An M-1 Garand. 7 kills with this one. All deer
A Browning BLR. 1 kill with this one. Elk.
A Classic Mauser with a 3X-9X scope. No kills yet with this one.

I have also owned 4 other 30-06s in my life that I have sold or traded.
A perfect condition 1903 Springfield. No kills with this one.
A full-stocked carbine on a Mauser, set up for cast bullets only. 2 kills. Both deer
A Winchester M70. 4 kills. 3 deer, 1 bear.
A Remington M1917 3 kills. 2 deer, 1 bear.

I have never seen a reason to regret the use of a 30-06 and I have never had a shot
offered to me that would would not take with a 30-06 that some other caliber would
have caused me to attempt.

I do not say the 30-06 is my all-time favorite center-fire hunting round, but it's in my top 3.