The 50gr. TSX and 62gr.HP Norma Varmageddon are the two most accurate bullets in my 22-250. The TSX is running only about 3,850fps and the 62's some 3,550fps.

The TSX I would use on a deer, but not the 62gr. varmint bullets.
I double my 14" twist triple deuce will shoot any of the TSX's - too long & not enough speed to get them stabilized. Any of the 55gr. Sp's would probably work, but I've the .22-250 or some real rifles for that job.

Last time I was hunting deer with a .22 CF, we (daughter & I) walked right into a grizzly's living room - his 'man cave' area - I really felt foolish.

For bears, I have a .50-95 Winchester, 9.3x62 or .375/06IMP. I even have a .303 Express on a #4 and #4 in .303- so no need for the .22 on bigger and/or dangerous game.