500nitro,

My guess is that Alan (4seventy) thinks the 470NE should be NitroX 3rd choice instead of the 450NE.

As for the original question;

30-06 (M98), 375H&H (M98), 470NE (double) would be a good blend, with ammo available pretty much everywhere.

or just the 375H&H. Good enough for any game on earth both big and small! (although not as a stopper...)

Erik