The 6.5 Grendel is head and shoulders ahead of all the small cased cartridges when it gets past up close and starts to be way out there. The Grendel forums ( http://www.65grendel.com/forum/ )have hunt reports with shots on antelope etc out to past where the other options mentioned above would reach with the same killing authority. Inside 350yds there are plenty of small cased options but past there the Grendel really starts to show is balistic advantage. Hornady in particular has introduced bullets (and ammo) specifically for the Grendel and is about to release a special 123gn sst as well. With the new Nosler offering there is even more options in very good to excellent hunting bullets. Of course target bullets are in abundance.