Anything can be done, but a 375 Ruger 760 would require major changes to accomplish, and uber time to get to feed dependably. The 376 Steyr is about the largest "practical"case for 760 conversion, and the 9.3x62 makes even more sense...especially if you want to a 270 or 280 companion barrel. A 9.3 and 270 would both feed from the same clip, use the same bolt, etc.