I think Mehul's original reply (before the minor skirmish!) is the best yet in terms of a lover of rifles, all things considered.

In terms of a cold, analytical response I'd say the .375 H&H is about as good as it gets for cartridges. An early G&H or Hoffman on an original mag mauser action, or an early model 70 would get my vote for the rifle. With that cartridge and rifle you can kill just about anything that walks, you can find the ammo anywhere, and the cartridge itself is beautiful to behold.

Of course it won't work for squirrels, etc. so you'll need a .22 I like the Mauser MM410B myself.