That's my concern too Daryl. I currently load:

38 grains of 2208 (Varget) under the 75's for a chronographed muzzle velocity of 3,235 fps.
36.5grains of Varget under the 87's for a MV of 3,031fps. (Right on factory specs).
My test medium was at 100 yards.

These are the loads that shoot consistantly very well in this rifle. The 87's under an inch and the 75's around half that. I can't really expect more off a bipod from a Mauser '98 without getting anal. The 75's are 'on' at 100 and 150 yards and 2.5" low at 200 yards. For head shots that puts the cross hair of the reticle on the top of the head at 200 yards+. That's a long shot for me. I could dick around with different 87 projectiles and powders for them, but without sample packs it would get expensive and take time.

I can't understand why the 250-3000 isn't more popular. As Blacks alluded to, the .303-25 was very popular here in Australia and as a Canadian you can appreciate the .303 based wildcats. The .303-25 was flat enough for foxes and back then illegally shooting 'roos, yet big enough for goats and pigs. I loaded my old .303-25 with a very accurate and mild load of 40 grains of 2209 (H4350) under the 87 Speer HP TNT for a chrono'd velocity of 2,730 fps. Not enough velocity for violent expansion but very useable.

I think a lot of people are enamored with text book/published ballistics and velocitys without taking into account the performance of a cartridge in real world conditions off the range.