A rather big and interesting question for sure. Well unless big bruins or bovines are a regular on the menu then a well put together Dakota bolt actioned .30 cal magnum with say a 2.5-10x schmidt similar scope in Talley rings would be my pick. Simply because for the dollars spent one would end up with a rig that would serve one extremely well for many moons on most occasions near and far. If one is always having to stop big beasts then of course something with a far bigger hole would be approriate.