Szihn, seeing as how you're the bullet maven, what's your opinion on using .257 magnum 100-gr. Hornady Interbond spitzers on animals up to and including Kudu?

Well Ovny, I can't say I have a qualified opinion on that bullet because back in the 1986-1999 years, (when i was doing this stuff every day) it didn't exist.
However I can say that if a 100 grain bullet holds together it will kill moose. I know because i know 5 men that have done it with 9 moose. However, such light bullets will not penetrate very well after hitting a LARGE bone. They will hold together (like the Barnes X ) just because the bone slows them done a lot. If you can shoot well, and if you are willing to turn down "iffy" shots, the bullet you talk about will work in all likelihood.

If it were me however, I would want something larger. Unless there is some reason you need to use the 257, I'd recommend a larger bullet, also of a good tuff construction.

If you go to most slaughter houses you'll find that 1300-1700 pound cattle are often killed with a 22 Long rifle. However there is no more "controlled shot" then in a slaughter house. Just because you CAN kill an animal with a small gun or bullet doesn't mean it's the right choice for such hunting. Several men have proven that African elephant can be killed with 22 long rifles. That only proves it can be done, but it didn't prove it's a good elephant round.

In all hunting the bottom line is that it's 98% the man and 2% what he's using. if you are man enough to turn down any shot that you don't KNOW is going to kill well and quickly, and if you can shoot well, then use the 257 or anything else you like.

If I were faced with the same opportunity, I'd take my 270 winchester loaded with Nosler 160 grain bullets, or Barnes 150 grain bullets, or a 30-06 with any good 180-or 200 grain hunting bullet.

In every case, I'd take a rifle and ammo that was good for the biggest animal on the list, and shoot smaller animals with it too.
That's why I have the belief that my 375H&H is still the best "all around" rifle i have ever owned, and I have owned a LOT of rifles.
If I knew that there was no possibility of buff on the list, and the kudu was the big one on that list, I'd probably go for my 270 over every other rifle I have.