I'd probably go with an 8x68S with 220-gr. Swift A-Frames for all "standard" Plains Game. To me, this cartridge and load has a nice combination of velocity, penetration, and a proven bullet. I think a lot depends on where and what you're hunting, even when we're talking about PG. If I was somewhere with thicker vegetation and shorter shooting distances, I could always load some 250-gr Woodleighs.
I might re-think this choice though if any Eland (and especially Lord Derby) or Giraffe was on my list. I'd also probably change things if I was after Bongo or Mt. Nyala.
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