I bought a .30-06 as my first serious "world" hunting rifle. In handles everything below buffalo with more than adequate power and I would use it on buffalo if I had too. Did in fact hunt buffalo with 220 gr solids once but never connected with a buff.

In Australia and New Zealand I have hunted feral pigs, goats, cattle, donkeys, skippies, fallow deer, red deer, hog deer and sambar deer with it.

I used my .30-06 on my first safari to Zimbabwe and hunted zebra, impala, duiker, wildebeest, warthog, kudu and eland with it. In fact my PH wanted to prove a point with it as another PH in camp told him a.30-06 could take an eland. So he wanted a one shot kill on an eland. In the end the eland was nicely shot in the heart with a left rear quartering shot to the heart with a 200 gr Nosler Partition. A second shot (for insurance) was made through the shoulders to the dead on its feet animal. From memory I think eland weigh about 1600 lbs (?).

I personally prefer to use something like my .375 on eland in future sized game as the margin for error is a little greater.