I've used Nosler Partitions in both 165 and 180 gr on American game, and found both to be excellent. My 30-06 handloads using H4350 give 2800 fps to the 165 gr bullet, and 2700 fps to the 180 gr Partition, both with excellent accuracy. The Nosler Partition bullet in either weight from a good 30-06 rifle will get the job done with aplomb.