Light: .22rf - Need one for pests & small game.

Medium: .270 Win. - Good for anything in North America except the big nasties that can shred you to pieces.

Heavy: .375 H&H or Ruger - If you can't kill it with a .375 it doesn't need killing.

With these three I could hunt the world.

My only qualifications would be that the .270 & .375 would be shooting my handloads.

If the .22rf is not really part of the equation I would drop it and add a .223 for some varminting.