Ripp,
The cartridges favoured for pro roo shooting have got smaller over the years.
When I first started commercial shooting back in the late 1970's, the 243 Win was popular and it worked well for me at that time.

Later I changed to an early 22-250 Ruger 77 which worked great with 55 grainers.
I also used a Sako 222 Magnum shooting the same bullets and then later a BSA 222 Rem. Both worked well.

The 243 was very good for (frontal) head shots on big roos as penetration was better due to the heavier/stronger projectiles than the 22 cal.

My favourite was the 22-250, with the only downside being heavier throat erosion compared to 222 Rem.