The original loads for the 450 nitro showed a 480 grain bullet at 2150fps. According to those in the know, most of the ammo back then ran closer to 2000fps. Even a marlin level load in a 45/70 shoots a 420gr bullet at 2000fps. So I doubt the extra 60 grains of bullet would make a huge difference on game. And to think that all of that power can be housed in a rifle weighing 7.5 pounds is something to think about. If I were faced with needing to make a fast follow up shot, other than a double, I can't think of anything better than a lever.